Sodium borohydride → HCID 68120077, compound

Participants

Reaction Steps

8-[(6-(Trifluoromethyl)-1,2,3,4-tetrahydro-1-oxo-2-naphthal-enyl)methyl]-1-phenyl-1,3,8,-triazaspiro[4.5]decan-4-one, hydrochloride (1:1) (0.65 g, see example 184) is slurried in methanol (10 ml) and, with cooling, treated with a solution of sodium borohydride (0.27 g) in water (2 ml). The resulting mixture is stirred at room temperature under nitrogen for 16 hours, diluted with water (10 ml), and extracted with methylene chloride. Concentration of the dried organic solution followed by trituration with absolute ethanol yields the free base of the title alcohol as a tan powder (0.5 g), melting point 238°-240° C.

Provenance & Evidence