1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 21408211, compound

HRID 2072490Notes

Reaction equation

HRID 2072490 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][C:10]([F:16])=[CH:11][CH:12]=2)[C:7]1=[O:17])[CH3:4].[C:18]1([N:24]2[C:28]3([CH2:33]CNC[CH2:29]3)[C:27](=[O:34])[NH:26][CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:16][C:10]1[CH:9]=[C:8]2[C:13]([CH2:14][CH2:15][CH:6]([CH2:5][N:3]3[CH2:2][CH2:33][C:28]4([N:24]([C:18]5[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=5)[CH2:25][NH:26][C:27]4=[O:34])[CH2:29][CH2:4]3)[C:7]2=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 14737531HCID 14737531, compound

Product 1

HCID 21408211HCID 21408211, compoundYield 97.4%

Procedure

5.0 g of 2-[(dimethylamino)methyl]-7-fluoro-3,4-dihydro-1(2H)-naphthalenone hydrochloride (1:1) and 5.85 g of 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one are suspended in absolute ehtanol (55 ml) and stirred overnight while a slow stream of nitrogen is bubbled through. The solid that forms is filtered off and washed with ether to give the title compound (7.7 g), melting point 162°-165° C.

Workup

  1. customis bubbled through
  2. filtrationThe solid that forms is filtered off
  3. washwashed with ether

Sources & evidence

ORD record
ord-d945aa9e89e74b3da2bd7a89a7467dba
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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