1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 21408224, compound

HRID 2072501Notes

Reaction equation

HRID 2072501 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[CH:11][CH:12]=2)[C:7]1=[O:18])[CH3:4].[C:19]1([N:25]2[C:29]3([CH2:34]CNC[CH2:30]3)[C:28](=[O:35])[NH:27][CH2:26]2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[C:19]1([N:25]2[C:29]3([CH2:30][CH2:2][N:3]([CH2:5][CH:6]4[CH2:15][CH2:14][C:13]5[C:8](=[CH:9][C:10]([O:16][CH3:17])=[CH:11][CH:12]=5)[C:7]4=[O:18])[CH2:4][CH2:34]3)[C:28](=[O:35])[NH:27][CH2:26]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 14737533HCID 14737533, compound

Product 1

HCID 21408224HCID 21408224, compoundYield 71.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 15.0 g of 2-[(dimethylamino)methyl]-3,4-dihydro-7-methoxy-1(2H)-naphthalenone, hydrochloride (1:1), 13.0 g of 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, and 250 ml of absolute ethanol is heated on a steam bath until all solids dissolve. The resulting solution is stirred for 16 hours at room temperature under nitrogen. The resulting precipitates are collected and washed with additional absolute ethanol to give 16.7 g of the title compound.

Workup

  1. temperatureis heated on a steam bath until all solids
  2. dissolutiondissolve
  3. customThe resulting precipitates
  4. customare collected
  5. washwashed with additional absolute ethanol

Sources & evidence

ORD record
ord-2e77bbd0eeb746f0bba9378b67cc9d45
Source dataset
uspto-grants-1977_09
Patent number
US04051248

Reaction notes

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