反应详情

A solution of 2-bromo-4-thiocyanoaniline (11.5 g., 0.05 mole) and sodium cyanide (1.23 g., 0.025 mole) in methanol (100 ml.) is stirred at room temperature overnight. Sodium cyanide (0.025 mole) is then added and the reaction heated at reflux 2 hours and then cooled (0°-5° C.). Methyl iodide is added and stirring continued. Thin layer chromatography shows one product spot. Product is recovered by extraction with methylene chloride, 8.4 g.

1. temperaturethe reaction heated
2. temperatureat reflux 2 hours
3. temperaturecooled (0°-5° C.)
4. customProduct is recovered by extraction with methylene chloride, 8.4 g