関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | N,N-Dimethylcyclohexylamine | HCID 7415 | — |
| 反応物 | t-Butyl bromide | HCID 10485 | — |
| 反応物 | 4-Amino-3-chlorobenzenethiol | HCID 19858566 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Chloro-4-((1,1-dimethylethyl)thio)benzenamine | HCID 15063844 | — |
反応手順
Dimethylcyclohexylamine (22.86 g., 0.18 mole) in methylene chloride (125 ml.) is added dropwise to a stirred solution of 2-chloro-4-mercaptoaniline (27.0 g., 0.17 mole) and tert-butyl bromide (22.86 g., 0.18 mole) in methylene chloride (125 ml.) and the mixture is allowed to stir at room temperature for about 68 hours. An additional quantity of dimethylcyclohexylamine (2.3 g.) and tert-butyl bromide (2.5 g., 0.018 mole) is added and stirring is continued overnight. The reaction is poured into water, and the product is extracted with methylene chloride. The combined extracts are washed with dilute hydrochloric acid, water and dried. Removal of the drying agent and methylene chloride gives impure 2-chloro-4-tert-butylthioaniline as a beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04913728 |
|---|
| 出典データセット | uspto-grants-1990_04 |
|---|
| ORD ID | ord-a09d16db94f1471c959bd28658b35775 |
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| 出典メモ | uspto-grants-1990_04 |
|---|
