Methanol → HCID 19858589, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-[5-(2-chloro-4-(trifluoromethyl)phenoxy)-2-nitrophenylamino]butyric acid (2.50 gm, 5.97 mmol) in 50 ml toluene cooled to 0° C. was added triethylamine (0.83 ml, 5.97 mmol). Methyl chloroformate (0.51 ml, 6.57 mmol) was added. After 1 hour the reaction was warmed to room temperature, an excess of methanol was added and the mixture was allowed to stir overnight. The reaction mixture was diluted with water, ether extracted, shaken with brine and dried (MgSO4) filtered and concentrated under vacuum. The resulting viscous oil was purified by column chromatography, silica gel, 40% ether/hexane to afford 2 gm of the desired product.

Provenance & Evidence