Hydrochloric Acid → HCID 54243536, compound

Participants

Reaction Steps

A mixture of 21.5 g of 2-bromo-1-(4-methoxyphenyl)ethane and 100 ml of toluene has added to it, under argon, 13.2 g of ZnBr2 and 1.4 g of lithium and is treated for 1 hour with ultrasound. A mixture of 21.4 g of 2-butyl-5-bromopyridine and 50 ml of toluene is then added, followed by a solution of 0.2 g of nickel(II) acetonylacetonate in 20 ml of THF. After a further hour 100 ml of dilute hydrochloric acid are added a little at a time, and the organic phase is worked up. Separation by column chromatography (silica gel, toluene) and recrystallization gives 5-(p-methoxyphenylethyl)-2-butylpyridine.

Provenance & Evidence