HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 54016733, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (R)-(-)-2-Chloropropan-1-ol | HCID 181530 | — |
| Reactant | HCID 15065826 | HCID 15065826 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 54016733 | HCID 54016733 | 68% |
Reaction Steps
61.5 m moles (22.6 g) of 4'-carbobenzoxyoxybiphenyl-4-carboxylic acid chloride was added dropwise into a THF solution of 61.5 m moles (5.2 g) of (R)-(-)-2-chloro-1-propanol and 10 ml of triethylamine, and stirred for 6 hours. After the reaction, the reaction solution was ether extracted. The extrate was purified by column chromatography to obtain 15.9 g of the ester compound [[α]D23 =+22.5° (CHCl3)]. (yield: 61%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04913839 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-a6a5ae677f73427b89bd4fd685e64d0f |
| Source note | uspto-grants-1990_04 |