HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 4-Carbobenzoxyoxybenzoic acid 1-methylpropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (+)-2-Butanol | HCID 444683 | — |
| Reactant | 4-Carbobenzoxyoxybenzoyl chloride | HCID 19734054 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Carbobenzoxyoxybenzoic acid 1-methylpropyl ester | HCID 54239335 | 18% |
Reaction Steps
A THF solution of 0.1 mole of (S)-(+)-2-butanol and 0.1 mole of triethylamine was stirred at 0° C., and a THF solution of 0.12 mole of 4-carbobenzoxyoxybenzoic acid chloride was added dropwise. The temperature was returned to the room temperature slowly, and stirring was carried out for 8 hours. After the reaction, the reaction solution was ether extracted, dried, concentrated, and purified by column chromatography, to obtain 5.7 g of 4-carbobenzoxyoxybenzoic acid 1-methylpropyl ester. (yield: 18%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04913839 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-71571906a3ff482eb80d99bc54aa5c6a |
| Source note | uspto-grants-1990_04 |