p-Toluenesulfonic acid → HCID 14168443, compound

Participants

Reaction Steps

A solution of 2-[(Methylamino)sulfonyl]-benzo-[b]thiophene-3-acetic acid (450 mg, 1.58 mmoles) and p-toluenesulfonic acid (45 mg) in xylenes (100 ml) was refluxed in a Dean-Stark trap for 6 hours. The solvent was evaporated and the resulting solid recrystallized from isopropanol to give the title compound (318 mg) in a yield of 765, mp 175°-178° C.; ms:m/e 267 (m+,25), 210(8), 160(5), 146(100); 1H-nmr(deuteriochloroform): δ7.96 (m,1H), 7,80 (m,1H), 7.58 (m,2H), 4.22 (s,2H), 3.38 (5,3H); ir (potassium bromide): 1700 cm-1.

Provenance & Evidence