Hydrochloric Acid → HCID 14878289, compound

Participants

Reaction Conditions

Reaction Steps

1.91 g of 6-[3-chloro-4-(carboxymethoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone (Compound No. 1a, prepared as described in Example 2) was dissolved in 55 ml of a 2% w/v aqueous sodium hydroxide solution, and 1.6 g of sodium m-nitrobenzenesulfonate was added thereto. The mixture was heated, with stirring, over an oil bath at 120° C. for 2 hours. The mixture was then cooled to room temperature and then acidified with 6N hydrochloric acid to a pH value of 2-3. The resulting precipitate was collected by filtration, to give 1.2 g of the title compound, melting at 227°=232° C.

Provenance & Evidence