Ethanol → HCID 10084622, compound

HRID 2072713Notes

Reaction equation

HRID 2072713 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[CH2:19](O)[CH3:20]>>[CH2:19]([O:10][C:9](=[O:11])[CH:8]([C:6]1[CH:5]=[CH:4][C:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[C:2]([F:1])[CH:7]=1)[CH3:12])[CH3:20]

Participants

3

Reactant 2

HCID 702EthanolHCID 3394Flurbiprofen

Product 1

HCID 10084622HCID 10084622, compound

Conditions

Temperature
50 °C

Procedure

To 2-(2-fluoro-4-biphenylyl)-propionic acid (30.0 g, 0.123 mol) in ethanol (300 ml) was added conc. sulfonic acid (3.0 g). After the addition, the mixture was stirring at 50° C. for 5 h, the concentrated and extracted with benzene. The benzene extracts were washed with aqueous sodium hydrogen carbonate solution then with water, and dried over. The extracts were evaporated under reduced pressure to afford ethyl-2-(2-fluoro-4-biphenylyl)propionate (33.6 g, 0.123 mol) as oily residue.

Workup

  1. additionAfter the addition
  2. concentrationthe concentrated
  3. extractionextracted with benzene
  4. washThe benzene extracts were washed with aqueous sodium hydrogen carbonate solution
  5. dry with materialwith water, and dried over
  6. customThe extracts were evaporated under reduced pressure

Sources & evidence

ORD record
ord-8f7f33b48924416ebde10d6d1f1d6f9a
Source dataset
uspto-grants-1990_04
Patent number
US04914112

Reaction notes

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