Chloroacetyl chloride → HCID 19913606, compound

Participants

Reaction Steps

Chloroacetyl chloride (0.21 g, 0.15 ml) in dichloromethane (5 ml) was added dropwise, under nitrogen to a stirred, ice-cooled solution of 3-chloro-α-[[[1,1-dimethylethyl]amino]methyl]benzenemethanol (0.5 g) and triethylamine (0.38 g, 0.53 ml) in dichloromethane (40 ml). The reaction mixture was stirred at ambient temperature for 2 h., washed with hydrochloric acid (2N), brine, dried (MgSO4), evaporated and chromatographed on silica. Elution with chloroform gave α-chloro-N-[2-(3-chlorophenyl)-2-hydroxyethyl]-N-[1,1-dimethylethyl]acetamide as a colourless oil.

Provenance & Evidence