HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2072821Generated: October 31, 2026
Sodium Carbonate → N-Boc-3-Chloropropylamine
https://huagongshe.com/reaction/2072821
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Reactant | 1-Propanamine, 3-chloro-, hydrochloride | HCID 11469095 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | N-Boc-3-Chloropropylamine | HCID 10932310 | — |
Reaction Steps
The compound of the title, employed as the starting material in example 1, is prepared by slowly adding a solution of 3-chloro-propylamine hydrochloride (12.98 g, 0.1 mol) in dioxane/water (100 ml 2/1 v/v) to a vigorously stirred mixture of di-(tert-butyl)carbonate (24 g, 0.11 mol), 1N Na2CO3 (100 ml) and dioxane/water (200 ml, 2/1 v/v) cooled to 0° C. When the addition is over, the reaction mixture is stirred at room temperature for an additional hour, dioxane is removed under vacuum and the aqueous phase is extracted a few times with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04914226 |
|---|
| Source dataset | uspto-grants-1990_04 |
|---|
| ORD ID | ord-4d6fb86cf6ba406c881a884ea7e46f9b |
|---|
| Source note | uspto-grants-1990_04 |
|---|
