Formaldehyde → HCID 54096093, compound

HRID 2072823Notes

Reaction equation

HRID 2072823 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])[CH3:2].[CH2:14]=O.[OH-].[Na+]>[OH-].[Na+].C(O)(=O)C>[C:9]([O:8][C:6](=[O:7])[C:5](=[CH2:14])[C:4]([O:3][CH2:1][CH3:2])=[O:13])([CH3:12])([CH3:11])[CH3:10]

Participants

6

Reactant 3

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 96345tert-Butyl ethyl malonate

Product 1

HCID 54096093HCID 54096093, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideCatalystHCID 176Acetic AcidSolvent

Procedure

This compound employed as the starting material in example 7 is prepared as follows: 10% NaOH (2 drops) is added to malonic acid tert-butyl ethyl ester (20 g). Aqueous 40% formaldehyde (15 ml) is then added very slowly thereto while keeping the temperature of the reaction mixture ≤5° C. and the pH at about 8.5 by means of 10% NaOH. The reaction mixture is then stirred at room temperature for 24 hours. The resulting reaction mixture is acidified by the addition of few drops of glacial acetic acid and charged, together with Cu(CH3COO)2, into a suitable distilling apparatus.

Workup

  1. customis prepared
  2. customthe temperature of the reaction mixture ≤5° C.
  3. customThe resulting reaction mixture

Sources & evidence

ORD record
ord-1eb20c620abc40459c6a25ae76a5b888
Source dataset
uspto-grants-1990_04
Patent number
US04914226

Reaction notes

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