Thionyl Chloride → HCID 54368633, compound

Participants

Reaction Steps

5.6 g of the resulting (s)-2-ethoxypropionic acid was added to 10 ml of thionyl chloride, and the mixture was refluxed for 5 hours. Thionyl chloride was then evaporated under reduced pressure, and a solution of 9.0 g of hydroquinone in 50 ml of dry pyridine was added, and the mixture was stirred at 30° to 40° C. for 20 hours. The reaction mixture was dissolved in a large amount of ethyl acetate, washed with dilute hydrochloric acid several times and then with water, and dried over anhydrous sodium sulfate. The ethyl acetate solution was concentrated and from the residue, 4.6 g of the desired oily product was obtained by silica gel column chromatography using hexane/ethyl acetate as an eluent.

Provenance & Evidence