Hydroxyamine hydrochloride → 5-(2,4-Dichloro-5-fluorophenyl)-isoxazole

Participants

Reaction Steps

A mixture of 57.6 g of 2-chlorovinyl 2,4-dichloro-5-fluoro-phenyl ketone, 16.4 g of hydroxylamine hydrochloride and 150 ml of methanol is heated at the boiling point under reflux for 6 hours, a precipitate separating out after about one hour. This is filtered off cold with suction, washed with a little methanol and dried at 50° C. in vacuo. 33.3 g (63.2%) of 5-(2,4-dichloro-5-fluorophenyl)-isoxazole of melting point 112°-113° C., which, according to investigations by NMR spectroscopy, contains about 6 mole % of an isomer, are obtained.

Provenance & Evidence