反应详情

To 40 ml of a benzene solution of phosgene (containing 6.2 g (62.5 millimoles) of phosgene), 6.4 g (50 millimoles) of ethyl 4-hydroxy-2-butynoate was rapidly added under cooling with ice, and the mixture was stirred for 30 minutes under cooling with ice. The reaction mixture was returned to room temperature and left to stand for one night. Then, the reaction mixture was concentrated under reduced pressure to distil off benzene, whereby 8.1 g (yield: 85%) of oily ethyl 4-(chlorocarbonyloxy)-2-butynoate was obtained as the residue.

1. temperatureunder cooling with ice
2. temperatureunder cooling with ice
3. customwas returned to room temperature
4. waitleft
5. waitto stand for one night
6. concentrationThen, the reaction mixture was concentrated under reduced pressure
7. customto distil off benzene