HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 2-(3,4-Dichlorophenyl)-3-[2-oxo-2-(1-piperidinyl)ethyl]-3H-imidazo[4,5-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 2-(3,4-dichlorophenyl)3H-imidazo[4,5-b]pyridine-3-acetic acid | HCID 15617193 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3,4-Dichlorophenyl)-3-[2-oxo-2-(1-piperidinyl)ethyl]-3H-imidazo[4,5-b]pyridine | HCID 14390338 | — |
Reaction Steps
Under nitrogen bubbling, a mixture of 2-(3,4-dichlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid (3.5 g, 0.011 mole) and 1,1'-carbonyldiimidazole (1.95 g, 0.011 mole) in 150 ml of tetrahydrofuran was stirred at room temperature for 4 hrs. Piperidine (1.87 g, 0.022 mole) was added and the reaction was allowed to stir at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04914109 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-1f7670c14c39485b82faa6a64ac6cf9f |
| Source note | uspto-grants-1990_04 |