18-Crown-6 → 6-{4-[2-(4-Nitrophenyl)ethenyl]phenoxy}hexan-1-OL

HRID 2073126노트

반응식

HRID 2073126 반응식
[K].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.I[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][OH:27].C1OCCOCCOCCOCCOCCOC1>C1(C)C=CC=CC=1>[OH:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 2855718-Crown-6HCID 130890816-Iodo-1-hexanolHCID 679201064-Hydroxy-4'-nitrostilbene potassium salt

생성물 1

HCID 539381646-{4-[2-(4-Nitrophenyl)ethenyl]phenoxy}hexan-1-OL

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To 500 ml of toluene in a 1000 ml round bottom flask, fitted with a condenser and magnetic stirrer, are added 14 g (0.05M) of 4-hydroxy-4'-nitrostilbene potassium salt, 14 g of 6-iodo-1-hexanol, and 0.5 g of 18-crown-6 ether. The mixture is refluxed for about 10 hours, and the solution is filtered hot and the product crystallizes from the toluene solution on cooling, mp 154°-157° C.

후처리

  1. temperatureThe mixture is refluxed for about 10 hours
  2. filtrationthe solution is filtered hot
  3. customthe product crystallizes from the toluene solution
  4. temperatureon cooling

출처 및 근거

ORD 기록
ord-1d2b105da56d4f2ebd12e85aa735a903
출처 데이터셋
uspto-grants-1990_04
특허 번호
US04915491

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