HCID 11041530, compound → HCID 15617572, compound

Participants

Reaction Steps

Analogously to Example 1, 5-(2,3,4,5-tetrahydro-1H-1-benzazepin-7-yl)-6-methyl-3,6-dihydro-1,3,4-thiadiazin-2-one ("E"), m.p. 142°, is obtained from 7-(2-chloropropionyl)-2,3,4,5-tetrahydro-1H-1-benzazepin [obtainable by reaction of 1-acetyl-2,3,4,5-tetrahydro-1H-1-benzazepine with 2-chloropropionyl chloride/AlCl3 to give 1-acetyl-2,3,4,5-tetrahydro-7-(2-chloropropionyl)-1H-1-benzazepine (in addition, the 8-(2-chloropropionyl) isomer is obtained, which can be separated chromatographically) and subsequent removal of the acetyl group with HCl].

Provenance & Evidence