Sodium cyanoborohydride → HCID 136054883, compound

Participants

Reaction Steps

A 136.3 g amount of 7-(3-fluorophenyl) pyrazolo[1,5-a]pyrimidine-3-carboxamide (prepared as described in Example 5) in one liter of glacial acetic acid was stirred at room temperature, then 83.6 g of sodium cyanoborohydride was added portionwise under nitrogen. The mixture was stirred for 16 hours then the precipitated crystals were collected by filtration and triturated with saturated sodium bicarbonate until pH 7-8 was achieved. The crystals were washed with water and dried in vacuo to give 63.0 g of the product as cream-colored crystals, m.p. 122°-125° C.

Provenance & Evidence