p-Anisoyl chloride → HCID 15702798, compound

HRID 2073201Notes

Reaction equation

HRID 2073201 reaction equation
[NH2:1][C:2]1[N:12]2[C:13]3[N:8]([C:9]([C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=4)=[CH:10][CH2:11]2)[N:7]=[CH:6][C:5]=3[C:4](=[O:24])[N:3]=1.[CH3:25][O:26][C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1>N1C=CC=CC=1>[CH3:25][O:26][C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:1][C:2]2[N:12]3[C:13]4[N:8]([C:9]([C:14]5[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=5)=[CH:10][CH2:11]3)[N:7]=[CH:6][C:5]=4[C:4](=[O:24])[N:3]=2)=[O:32])=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 9905671HCID 9905671, compound

Product 1

HCID 15702798HCID 15702798, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 200 mg amount of 5-amino-8-[3-(trifluoro-methyl)phenyl]-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one (prepared as described in Example 29) was suspended in 3 ml of pyridine, then 0.2 ml of p-methoxybenzoyl chloride was added in one portion and the reaction mixture was stirred at room temperature for 16 hours. The reaction was quenched in 100 ml of water and the solid which formed was collected by filtration and washed with ether to give 164 mg of the desired product as a white solid, m.p. 271°-273° C.

Workup

  1. customThe reaction was quenched in 100 ml of water
  2. customthe solid which formed
  3. filtrationwas collected by filtration
  4. washwashed with ether

Sources & evidence

ORD record
ord-205b4c60ad8546cc91090519d53d8db3
Source dataset
uspto-grants-1990_04
Patent number
US04916137

Reaction notes

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