Water → HCID 14724139, compound

Participants

Reaction Steps

A solution of 4-chloroquinoline (10 g) and 1-aminopyrrole (6 g) in 100 ml isopropanol containing 1 ml saturated ether/HCl was stirred at 80° for thirty minutes, and thereafter cooled, stirred with water, basified with sodium carbonate and extracted with dichloromethane. The organic extract was washed successively with water and saturated sodium chloride solution, dried (anhy. MgSO4), filtered and concentrated to 12 g of solid, m.p. 165°-168°. Four grams were converted to the hydrochloride salt and recrystallized twice from methanol/ether to give 2.9 g crystals, m.p. 233°-234°.

Provenance & Evidence