Carbazole → HCID 14724156, compound

Participants

Reaction Steps

A solution of 9H-carbazol-9-amine (11 g, as an unquantified mixture with carbazole) and 4-chloroquinoline (10 g) in 100 ml isopropanol acidified with ether/HCl was refluxed for seven hours, and thereafter cooled, stirred with water, basified with sodium carbonate and extracted with ethyl acetate. The organic extract was washed successively with water and saturated sodium chloride solution, dried (anhy. MgSO4), filtered and concentrated to 20 g solid. This material was converted to the hydrochloride salt in methanol/ether to give 6 g solid, m.p. >260°. Three grams were recrystallized from methanol/ether to give 2.6 g white needles, dec. 300°-302°.

Provenance & Evidence