Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 14724179 | HCID 14724179 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 14724199 | HCID 14724199 | — |
Reaction Steps
To a solution of 7-chloro-N-(2-propynyl)-N-(1H-pyrrol-1-yl)-4-quinolinamine (8.0 g) in 150 ml of 1,4-dioxane were added N-methylpiperazine (3.11 g), paraformaldehyde (4 g) and CuCl (0.2 g), and this mixture was heated to 80° C. and stirred for four hours. The mixture was cooled, diluted with ethyl acetate, washed with water and dried (sat NaCl, anhy. MgSO4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04916135 |
|---|
| Source dataset | uspto-grants-1990_04 |
|---|
| ORD ID | ord-881c7a2cfcb246af8e3288eb52a8bbb6 |
|---|
| Source note | uspto-grants-1990_04 |
|---|
