HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 19909379, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | 3-Chloro-N,N-dimethyl-1-propanamine | HCID 66960 | — |
| Reactant | (3,4-Dichlorophenyl)acetonitrile | HCID 76690 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 19909379 | HCID 19909379 | 63% |
Reaction Steps
3.9 g of sodium amide are added in small portions to a solution of 18.6 g of 3,4-dichlorophenylacetonitrile in 200 ml of anhydrous ether. The mixture is refluxed for 2 hours, 12.1 g of 3-chlorodimethylaminopropane are added and refluxing is continued for 2 and a half hours. The mixture is cooled, water is added and the organic phase is decanted. It is washed with water and extracted with 10% hydrochloric acid. The aqueous phase is then neutralized with 30% sodium hydroxide and extracted with ether and the solvent is evaporated off to give 17 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04916156 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-61ab3737b55649ccaa9f93a9976848cc |
| Source note | uspto-grants-1990_04 |