HCID 19858089, compound → HCID 19858104, compound

Participants

Reaction Conditions

Reaction Steps

A suspension containing 5.4 g of 1-(4'-chloro-3'-sulfamoylbenzoyl)amino-5-methoxycarbonyl-2-methylsulfonylbenzimidazole in 30 ml of 2N sodium hydroxide solution was stirred at 50° C. for 4 hours to give a clear violet solution which was clarified by activated carbon, filtered and the filtrate was acidified to pH 2 by adding 2N hydrochloric acid. The white precipitate was filtered by suction, washed with water and dried to give 4.43 g (85.7%) of 5-carboxy-1-(4'-chloro-3'-sulfamoylbenzoyl)amino-2-methylsulfonylbenzimidazole, as a white powdery solid, m.p.: 222°-225° C. (with decomposition) which is not changed after recrystallization from a mixture of dimethylformamide and water (3:2).

Provenance & Evidence