Acetic Anhydride → HCID 67895803, compound

HRID 2073235Notes

Reaction equation

HRID 2073235 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[NH2:8][C:9]1[CH:14]=[C:13]([C:15]([OH:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]([C:20](=[O:22])[CH3:21])[NH2:19]>ClCCl>[C:1]([NH:8][C:9]1[CH:14]=[C:13]([C:15]([OH:17])=[O:16])[CH:12]=[CH:11][C:10]=1[N:18]([C:20](=[O:22])[CH3:21])[NH2:19])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 67895813HCID 67895813, compound

Product 1

HCID 67895803HCID 67895803, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

235 ml of acetic anhydride were added to a suspension of 97.5 g of 2-amino-4-carboxy-N-acetylphenylhydrazine in 450 ml of dichloromethane while stirring. The mixture was stirred at room temperature for 3 hours, then the crystals were filtered by suction, washed with dichloromethane and dried at 60° C. Thus, 101.2 g (86.5%) of 2-acetylamino-4-carboxy-N-acetylphenylhydrazine were obtained, m.p.: 238° C. (with decomposition).

Workup

  1. stirringThe mixture was stirred at room temperature for 3 hours
  2. filtrationthe crystals were filtered by suction
  3. washwashed with dichloromethane
  4. customdried at 60° C

Sources & evidence

ORD record
ord-ac49d098f340494e97a3133b77032094
Source dataset
uspto-grants-1990_04
Patent number
US04916149

Reaction notes

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