Ethanol → HCID 19858152, compound

Participants

Reaction Steps

After adding 69.96 g of 2-amino-4-trifluoromethyl-N-acetylphenylhydrazine to a solution of 19.07 g of potassium hydroxide in 300 ml of abs. ethanol, 20.5 ml of carbon disulfide were dropped to the mixture under stirring. The red solution obtained was refluxed for 5 hours, the hot solution was clarified by activated carbon and filtered. After adding 370 ml of water and then 70 ml of a mixture of acetic acid and water (1:2) to the filtrate, the crystalline precipitate was filtered by suction, washed with water and dried at 80° C. Thus, 55.5 g (67%) of 1-acetylamino-5-trifluoromethylbenzimidazole-2-thione were obtained, m.p.: 294°-295° C. after recrystallization from 50% of aqueous ethanol.

Provenance & Evidence