HCID 67863379, compound → HCID 67863344, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (2S,4R)-1-(4-chlorophenyl-sulfonyl)-4-(4-chlorophenylsulfonylamino)-2-[(Z)-2-(4methoxycarbonylphenyl)vinyl]pyrrolidine (15.0 g) in a mixture of methanol (100 ml) and 1N aqueous sodium hydroxide (75 ml) was stirred at 50° C. for 4 hours and the volatile solvent was evaporated in vacuo. The residual aqueous solution was adjusted to pH 1 with concentrated hydrochloric acid. The white precipitate was collected by filtration and washed with water to give (2S,4R)-2-[(Z)-2-(4-carboxyphenyl)vinyl]-1-(4-chlorophenylsulfonyl)-4-(4-chlorophenylsulfonylamino)pyrrolidine (14.50 g) as a white powder.

Provenance & Evidence