Aluminium lithium hydride → HCID 67863336, compound

Participants

Reaction Steps

To a solution of (2S,4R)-1-(4-chlorophenylsulfonyl)-4-(4-chlorophenylsulfonylamino)-2-[(Z)-5-methoxycarbonyl-1-pentenyl]pyrrolidine 500 mg) in dry tetrahydrofuran (20 ml) was added lithium aluminum hydride (34 mg) under ice bath cooling. After the mixture was stirred in an ice bath for 30 minutes, aqueous tetrahydrofuran was added thereto and the mixture was filtered through Celite. The filtrate was washed successively with water and brine and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was solidified with ether to give (2S,4R)-1-(4-chlorophenylsulfonyl)-4-(4-chlorophenylsulfonylamino)-2-[(Z)-6-hydroxy-1-hexenyl]pyrrolidine (350 mg).

Provenance & Evidence