HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) → HCID 14699557, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-hydrazinyl-, ethyl ester, hydrochloride (1:1) | HCID 11593468 | — |
| Reactant | 3-(Dimethylamino)-2-(4-fluorophenyl)-1-phenylprop-2-en-1-one | HCID 54571342 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | HCID 14699557 | HCID 14699557 | 95.7% |
Reaction Steps
Following the procedure of example 1B, 13.8 g (0.0645 mol) of 2-(4-fluorophenyl)-1-phenylethanone was reacted with 20 mL of dimethyl formamide dimethyl acetal to yield 13.6 g of 3-(dimethylamino)-2-(4-fluorophenyl)-1-phenyl-2-propen-1-one, mp 115°-116° from isopropyl acetate. The enamine (10.5 g, 0.039 mol) was reacted with 6.03 g (0.039 mol) of ethyl hydrazinoacetate hydrochloride to yield 12.1 g of product mp 86°-87° C. from methyl-t-butyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04916150 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-fac76e892f784f3096406a3020d05222 |
| Source note | uspto-grants-1990_04 |