HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethyl-1,3-propanediamine → N-[3-(Diethylamino)propyl]-4-(4-fluorophenyl)-5-phenyl-1H-pyrazole-1-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethyl-1,3-propanediamine | HCID 61011 | — |
| Reactant | HCID 14699557 | HCID 14699557 | — |
| Product | N-[3-(Diethylamino)propyl]-4-(4-fluorophenyl)-5-phenyl-1H-pyrazole-1-acetamide | HCID 14699594 | — |
Reaction Steps
A solution of 8.73 g (0.027 mol) of ethyl 4-(4-fluorophenyl)-5-phenyl-1H-pyrazole-1-acetate of example 6 in 30 mL of 3-(diethylamino)propanamine was heated at reflux for 3 hr. The excess amine was stripped under vacuum and the residue triturated in 1:1 hexane/methyl t-butyl ether. The solid was recrystallized from triethylamine to yield 8.4 g of product, mp 82°-83° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04916150 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-41f4301f1a7b41ffa4557bcf4c579a1a |
| Source note | uspto-grants-1990_04 |