3',4'-Dimethyl-biphenyl-4-carboxylic acid → 3',4'-Dimethyl-N-[6-(3-pyridinyl)hexy11[1.1'-biphenyl]-4-carboxamide

HRID 2073295Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([OH:17])=O)=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][NH2:30])[CH:19]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[CH:11][C:12]([C:15]([NH:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][C:20]3[CH:19]=[N:18][CH:23]=[CH:22][CH:21]=3)=[O:17])=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

Reactant 2

HCID 27585473',4'-Dimethyl-biphenyl-4-carboxylic acid

HCID 135574533-Pyridinehexanamine

Product 1

HCID 147507753',4'-Dimethyl-N-[6-(3-pyridinyl)hexy11[1.1'-biphenyl]-4-carboxamide

Procedure

The title compound was prepared from 7.0 g of 3',4'-dimethyl[1,1'-biphenyl]-4-carboxylic acid and 6.1 g of 3-pyridinehexanamine according to Example 3 to give 6.2 g of 3,'4'-dimethyl-N-[6-(3-pyridinyl)hexyl][1,1'-biphenyl]-4-carboxamide. mp 81°-82° C.

Sources & evidence

ORD record: ord-e38611c7997c4abe91f6ee0553c3af42
Source dataset: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04916145

Reaction notes

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