HCID 14547259, compound → HCID 14547258, compound

Participants

Reaction Steps

As in Example 112, a solution of 195 g of [R-(R..R.)]-alpha-hydroxy-N-[1-ethyl-4-(3-pyridinyl)butyl]benzeneacetamide in 1.1L of 6N HCl was treated with 104 mL of conc. HCl and then was heated at reflux for 2 days. The crude amine, obtained by the normal work up, was distilled to give 109 g of (R)-alphaethyl-3-pyridinebutanamine, (bP 105° C./0.2mm); [α]D25 -11.9° (c. 1.0, MeOH)

Provenance & Evidence