反应详情

A solution of 0.4 g of 3-(8-isoquinolinyl)-2-propyn-1-ol in a mixture of 10 mL of ethanol and 5 mL of methanol was hydrogenated over 0.06 g 10% Pd/C at room temperature and atmospheric pressure for 22 hours and then at 50 psi for 20 hours. After the catalyst was removed by filtration and the filtrate was concentrated, the residual oil was purified by HPLC (methanol-chloroform; 1:19) and crystallized from ethyl acetate-hexane to yield 0.136 g of 8-isoquinolinepropanol, mp 66°-69° C.

1. waitat 50 psi for 20 hours
2. customAfter the catalyst was removed by filtration
3. concentrationthe filtrate was concentrated
4. customthe residual oil was purified by HPLC (methanol-chloroform; 1:19)
5. customcrystallized from ethyl acetate-hexane