Cyclopropylamine → HCID 178472124, compound

HRID 2073332Notes

Reaction equation

HRID 2073332 reaction equation
[ClH:1].[CH2:2]([O:4][C:5](=[O:11])[CH2:6][C:7](OC)=[NH:8])[CH3:3].[CH:12]1([NH2:15])[CH2:14][CH2:13]1>C(O)C>[ClH:1].[CH2:2]([O:4][C:5](=[O:11])[CH2:6][C:7]([NH:15][CH:12]1[CH2:14][CH2:13]1)=[NH:8])[CH3:3]

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 12367134Ethyl 3-imino-3-methoxypropanoate--hydrogen chloride (1/1)

Product 1

HCID 178472124HCID 178472124, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 13.3 g of 3-methoxy-3-imino propanoic acid ethyl ester hydrochloride in absolute ethanol was added 4.18 g of cyclopropylamine. The modest exotherm was controlled using a cold water bath and the reaction was stirred overnight. The ethanol was removed with rotary-evaporation to give a viscous oil. This oil was triturated with ethyl ether (1000 ml) to give a colorless solid. Yield=13.44 g.

Workup

  1. customThe ethanol was removed with rotary-evaporation
  2. customto give a viscous oil
  3. customThis oil was triturated with ethyl ether (1000 ml)
  4. customto give a colorless solid

Sources & evidence

ORD record
ord-dc5a0e5a0d7d4e938b3c35869c4132af
Source dataset
uspto-grants-1990_04
Patent number
US04916229

Reaction notes

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