Sodium hydroxide--water (1/1/1) → HCID 178524532, compound

Participants

Reaction Steps

To a solution of 95% ethanol (20 ml) and 2N NaOH/H2O (40 ml) was added 2.65 g of ethyl 2-cyclopropylamino-5-fluoro-6-hydroxynicotinate. The inital suspension was refluxed for a total of six hours, then cooled, and evaporated to a solid. The solid was dissolved in 30 ml of H2O and acidified to pH=1 with 2N HCl solution. The solid formed upon acidification was collected by filtration and washed with H2O to give the crude acid product. This product was triturated with hot 95% ethanol, filtered, and dried to give 1.65 g of a beige colored solid, 2-cyclopropyl-5-amino-6-hydroxynicotinic acid.

Provenance & Evidence