Methyl carbazate → HCID 14294138, compound

Participants

Reaction Steps

A mixture of 50 g of the above ester, 18.g. of methyl hydrazinocarboxylate and 300 ml of dichloromethane was refluxed for 2 hours, then washed twice with water, once with saturated sodium chloride and dried. The resulting oily residue was concentrated under high vacuum at 50° C. for 2 hours and the semi-solid crystallized from toluene-hexane, giving 36 g of the desired compound as ivory colored crystals, mp 94.5-95° C. Proton nuclear magnetic resonance (δ[ppm], CDCl3) 90MHz: 3.78 (s, 3H, OCH3); 3.80 (s, 3H, OCH3); 4.03 (s, 2H, CH2CS); [6.89 (d, 2H, J=8.2Hz) and 7.21 (d, 2H)(C6H4)]8.60 (bs, 1H, NH); 9.40 (bs, 1H, NH).

Provenance & Evidence