2-Amino-4,6-dimethyl pyrimidine → HCID 13726719, compound

HRID 2073408Notes

Reaction equation

HRID 2073408 reaction equation
[Cl:1][C:2]1[C:6]([S:7]([N:10]=[C:11]=[O:12])(=[O:9])=[O:8])=[CH:5][S:4][N:3]=1.[CH3:13][C:14]1[CH:19]=[C:18]([CH3:20])[N:17]=[C:16]([NH2:21])[N:15]=1>C(Cl)Cl>[Cl:1][C:2]1[C:6]([S:7]([NH:10][C:11]([NH:21][C:16]2[N:17]=[C:18]([CH3:20])[CH:19]=[C:14]([CH3:13])[N:15]=2)=[O:12])(=[O:8])=[O:9])=[CH:5][S:4][N:3]=1

Participants

4

Reactant 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 146022913-Chloro-1,2-thiazole-4-sulfonyl isocyanate

Product 1

HCID 13726719HCID 13726719, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 10 ml portion of the methylene chloride solution of 3-chloro-4-isothiazolesulfonyl isocyanate, prepared in Example 2, was added to 0.2 g of 4.6-dimethyl-2-pyrimidinamine, and the mixture stirred 0.5 hour at ambient temperature. The solvent was evaporated and the residual solid triturated with ether, collected and dried giving 0.5 g of the title compound, m.p. 136°-140°. IR: 1720 and 1700 cm-1 (C=O).

Workup

  1. customThe solvent was evaporated
  2. customthe residual solid triturated with ether
  3. customcollected
  4. customdried

Sources & evidence

ORD record
ord-1a92b636964d40b2b4a706a7276ea473
Source dataset
uspto-grants-1990_04
Patent number
US04917719

Reaction notes

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