反应详情

A suspension of 52.0 g of 4-amino-3-isothiazolecarboxylic acid hydrochloride [prepared by the method of K. Gewald and P. Billman, Liebigs Ann. 1542 (1979)] in 300 ml methanol was cooled in an ice-bath and 10 ml of thionyl chloride was added dropwise. The reaction mixture was refluxed 3 hours, cooled and the solvent evaporated. The residual solid was collected, washed with ether and dried giving 47.5 g of methyl 4-amino-3-isothiazolecarboxylate hydrochloride, m.p. 170°(d).

1. customprepared by the method of K
2. temperatureThe reaction mixture was refluxed 3 hours
3. temperaturecooled
4. customthe solvent evaporated
5. customThe residual solid was collected
6. washwashed with ether
7. customdried