Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2073414Generated: November 1, 2026

Chloroacetic Acid → Glycine, N-(3-hydroxyphenyl)-

https://huagongshe.com/reaction/2073414

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChloroacetic AcidHCID 300—
ReactantSodium CarbonateHCID 10340—
Reactant3-AminophenolHCID 11568—
ReactantLithium hydroxide, monohydrateHCID 168937—
ReactantLithiumHCID 3028194—
SolventWaterHCID 962—
ProductGlycine, N-(3-hydroxyphenyl)-HCID 5318318—

Reaction Conditions

Temperature90 °C

Reaction Steps

9.2 g of monochloroacetic acid are introduced into 40 ml of water and converted into the lithium salt with 4.1 g of lithium hydroxide monohydrate. 10.4 g of 3-aminophenol are then added and the mixture is stirred at 90° C. for 2 hours. It is then cooled to 20° C. and brought to pH 7 with sodium carbonate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04917731
Source datasetuspto-grants-1990_04
ORD IDord-1d45e455a716486db05363252e164d61
Source noteuspto-grants-1990_04