Hydrochloric Acid → HCID 67884938, compound

Participants

Reaction Steps

A solution of the title compound from Example 96 (0.184 g) in absolute methanol (1 ml) is treated at 20°-25° under nitrogen with 0.53M anhydrous HCl in methanol (3.1 ml) until acid by pH paper. The resultingl solution becomes turbin within a minute and a precipitate begins to form. The resulting suspension is stirred for ~ 5 minutes, and anhydrous ether (45 ml) is added in portions over 30 minutes. The suspension is stirred for ~ 15 minutes and filtered. The filtercake is washed with anhydrous ether (~ 15 ml) and the residue is dried under high vacuum to give the title compound; NMR (d6DMSO, TMS) δ 0.90, 1.10-3.60, 3.70, 6.60-6.87, 7.23. (PLA2)

Provenance & Evidence