反应详情

57.9 g (0.221 mol) of 3,3-bis(4-fluorophenyl)propionic acid were dissolved in 200 ml of absolute ether and the solution was added dropwise to a suspension of 10.9 g (0.287 mol) of LiAlH4 in 150 ml of absolute ether. When the dropwise addition had ended, the mixture was subsequently stirred for a further 30 minutes and, for hydrolysis, 175 ml of saturated sodium potassium tartrate solution and 400 ml of 10% strength H2SO4 were added dropwise in succession. After filtration, the phases were separated and the ethereal phase was washed with NaHCO3 solution and NaCl solution, dried and concentrated.

1. additionWhen the dropwise addition
2. additionwere added dropwise in succession
3. filtrationAfter filtration
4. customthe phases were separated
5. washthe ethereal phase was washed with NaHCO3 solution and NaCl solution
6. customdried
7. concentrationconcentrated