HCID 13883284, compound → 1-[2,2-Bis(4-fluorophenyl)ethyl]piperazine

HRID 2073484Notes

Reaction equation

HRID 2073484 reaction equation
Cl.C([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH:16]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)[C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[F:30][C:27]1[CH:26]=[CH:25][C:24]([CH:16]([C:17]2[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=2)[CH2:15][N:12]2[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]2)=[CH:29][CH:28]=1

Participants

4

Reactant 1

HCID 13883284HCID 13883284, compound

Product 1

HCID 200879301-[2,2-Bis(4-fluorophenyl)ethyl]piperazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

35.1 g of 1-benzyl-4-[2,2-bis(4-fluorophenyl)ethyl]-piperazine hydrochloride were hydrogenated in 1,400 ml of methanol on 8 g of palladium-on-charcoal (10%) at room temperature for 1 hour. The catalyst was filtered off with suction, the solvent was evaporated off, the residue was dissolved in 200 ml of water, the pH was brought to 10 with 2N NaOH, the solution was extracted several times with methylene chloride and the extracts were dried and concentrated.

Workup

  1. filtrationThe catalyst was filtered off with suction
  2. customthe solvent was evaporated off
  3. dissolutionthe residue was dissolved in 200 ml of water
  4. extractionthe solution was extracted several times with methylene chloride
  5. customthe extracts were dried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-6295f216887b4fe6bcef45e15e540115
Source dataset
uspto-grants-1990_04
Patent number
US04918073

Reaction notes

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