4-Fluorobenzyl chloride → HCID 19857177, compound

Participants

Reaction Steps

A Grignard solution was prepared from 13.8 g (0.575 mol) of magnesium filings and 83.1 g (0.575 mol) of 4-fluorobenzyl chloride in 560 ml of absolute ether. This solution was added dropwise to a solution of 92 g (0.46 mol) of ω-chloro-4-fluorobutyrophenone in 300 ml of absolute ether and the mixture was heated under reflux for 2 hours. It was then poured onto 500 ml of ice, 1 liter of NH4Cl solution was added, the mixture was extracted several times with ether and the organic phases were dried and concentrated.

Provenance & Evidence