Sulfuric Acid → HCID 19857181, compound

Participants

Reaction Steps

165 g (0.53 mol) of 4,5-bis(4-fluorophenyl)-4-hydroxypentyl chloride were hydrogenated in 1,650 ml of glacial acetic acid, with the addition of 16.5 g of palladium-on-charcoal (10%) and 80 ml of concentrated H2SO4, at room temperature for 5 hours. The catalyst was filtered off with suction, the filtrate was concentrated to about one quarter of the volume, methylene chloride and water were added, the pH was brought to 6 with concentrated NaOH and the organic phase was separated off, washed with NaHCO3 solution and water, dried and concentrated.

Provenance & Evidence