HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[4,4-Bis(4-fluorophenyl)butyl]-4-ethoxycarbonylaminopiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,1'-(4-Bromobutylidene)bis[4-fluorobenzene] | HCID 93763 | — |
| Reactant | ethyl N-(piperidin-4-yl)carbamate | HCID 15595030 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 1-[4,4-Bis(4-fluorophenyl)butyl]-4-ethoxycarbonylaminopiperidine | HCID 13883285 | — |
Reaction Steps
11 g (64 mmol) of 4-ethoxycarbonylaminopiperidine, 20.5 g (64 mmol) of 4,4-bis(4-fluorophenyl)butyl bromide, 12.9 g (128 mmol) of triethylamine and 0.18 g of potassium iodide were stirred in 180 ml of absolute dimethylformamide at 80° C. for 36 hours, the mixture was diluted with about 1.5 liters of water, 100 ml of 2N NaOH were added and the mixture was extracted twice with methylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04918073 |
| Source dataset | uspto-grants-1990_04 |
| ORD ID | ord-8c64d4447cf1421f885c9da78776b5a9 |
| Source note | uspto-grants-1990_04 |