Potassium Carbonate → HCID 19857235, compound

Participants

Reaction Steps

A mixture of 2-carbomethoxymethoxybenzyl chloride (0.1 mol) and 3-carbomethoxypropoxy-4-hydroxybenzaldehyde (0.08 mol) in 8:1-acetone: dimethylformamide (900 mL) is refluxed with anhydrous potassium carbonate (0.1 mol). When the reaction is complete, the cooled reaction mixture is filtered and evaporated. The resulting oil is diluted with ethyl acetate and washed with water (6X's). The dried ethyl acetate solution is absorbed on silica gel and eluted through a column of flash silica (500 g) with a mixture of ethyl acetate: petroleum ether. Condensation of the appropriate fraction gives 3-carbomethoxypropoxy-4-(2-(carbomethoxymethoxy)phenyl)methyloxybenzaldehyde which is used directly in the next step.

Provenance & Evidence